Science has shown that immune cells play a central—but dual, paradoxical—role in either promoting or destroying tumors. When a patient develops cancer, the patient’s immune system has failed to identify and destroy tumor cells. Ironically, the patient’s immune system often ends up protecting tumors and helping them develop. Thunder Biotech’s MOTO-CAR immunotherapy is designed to reverse these tumor protecting responses by re-educating the patient’s immune system and restoring its ability to recognize and eliminate tumor cells.

Utilizing our advanced MOTO-CAR immunotherapy platform, Thunder Biotech’s mission is to engineer a patient’s macrophages to create MOTO-CARs, which target specific biomarkers on the surface of cancer cells and activate macrophages to fight cancer.

Thunder’s preliminary data reveal that MOTO-CARs reduce tumor burden in animal models. These findings demonstrate that MOTO-CARs effectively treat solid tumors.